Pik3ap1 Gene Summary [Mouse]
Enables identical protein binding activity and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of inflammatory response; and regulation of innate immune response. Located in cytosol and plasma membrane. Orthologous to human PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3ap1 |
| Official Name | phosphoinositide-3-kinase adaptor protein 1 [Source:MGI Symbol;Acc:MGI:1933177] |
| Ensembl ID | ENSMUSG00000025017 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase adaptor protein 1 |
| Synonyms | 1810044J04Rik, BCAP, phosphoinositide-3-kinase adaptor protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pik3ap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoinositide 3-kinase binding
- Dof, BCAP, and BANK (DBB) motif,
- Toll/interleukin-1 receptor domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Pik3ap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- endometrioma
- hypoplasia
- gout
- laser induced choroidal neovascularization
- hypertrophic scar
- orthostatic hypotension
role in cell
- expression in
- quantity
- proliferation
- apoptosis
- accumulation
- activation in
- number
- phosphorylation in
- differentiation
- replenishment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pik3ap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 9 signaling pathway
- toll-like receptor 2 signaling pathway
- toll-like receptor 7 signaling pathway
- toll-like receptor 4 signaling pathway
- regulation of inflammatory response
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- receptor binding