Nsun3 Gene Summary [Mouse]
Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation; regulation of mitochondrial translation; and tRNA wobble base cytosine methylation. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; neural ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 48. Orthologous to human NSUN3 (NOP2/Sun RNA methyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsun3 |
| Official Name | NOL1/NOP2/Sun domain family member 3 [Source:MGI Symbol;Acc:MGI:2146565] |
| Ensembl ID | ENSMUSG00000050312 |
| Bio databases IDs | |
| Aliases | NOL1/NOP2/Sun domain family member 3 |
| Synonyms | 6720484A09RIK, COXPD48, LOC102549993, LOC679671, MST077, MSTP077, NOL1/NOP2/Sun domain family member 3, NOP2/Sun RNA methyltransferase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsun3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (cytosine-5-)-methyltransferase
- NOL1/NOP2/sun family putative RNA methylase
- 16S rRNA methyltransferase RsmB/F
- enzyme
- AdoMet_MTases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- deep vein thrombosis
- combined oxidative phosphorylation deficiency 48
- hereditary disorder
- thromboembolism
role in cell
- acidification in
- glycolysis in
- number
- translation in
- synthesis in
- cellular respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsun3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wobble base cytosine methylation
- rRNA methylation
- regulation of mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- tRNA (cytosine-5-)-methyltransferase activity
- methyltransferase activity
- tRNA binding