Tacstd2 Gene Summary [Mouse]
Involved in several processes, including negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of cellular component organization; and negative regulation of substrate adhesion-dependent cell spreading. Acts upstream of or within positive regulation of stem cell differentiation. Located in several cellular components, including basal plasma membrane; extracellular space; and lateral plasma membrane. Is expressed in alimentary system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in corneal dystrophy and gelatinous drop-like corneal dystrophy. Orthologous to human TACSTD2 (tumor associated calcium signal transducer 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tacstd2 |
| Official Name | tumor-associated calcium signal transducer 2 [Source:MGI Symbol;Acc:MGI:1861606] |
| Ensembl ID | ENSMUSG00000051397 |
| Bio databases IDs | |
| Aliases | tumor-associated calcium signal transducer 2 |
| Synonyms | EGP-1, GA733-1, GP50, Ly97, M1S1, Prp1, TROP2, tumor-associated calcium signal transducer 2, tumour-associated calcium signal transducer 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tacstd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TY
- protein binding
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- colorectal neoplasia
- epithelial cancer
- epithelial neoplasia
- gastrointestinal neoplasia
- cancer
- gelatinous drop-like corneal dystrophy
- metastatic breast cancer
- breast cancer
role in cell
- migration
- differentiation
- proliferation
- assembly
- expression in
- phosphorylation in
- growth
- invasion by
- motility
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- Nucleus
- vesicles
- cytosol
- basal membrane
- lateral plasma membrane
- early endosomes
- late endosomes
- cell membrane leading edge
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tacstd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of stem cell differentiation
- negative regulation of stress fiber assembly
- negative regulation of substrate adhesion-dependent cell spreading
- negative regulation of epithelial cell migration
- negative regulation of cell motility
- regulation of epithelial cell proliferation
- ureteric bud morphogenesis
- visual perception
- negative regulation of ruffle assembly
- negative regulation of branching involved in ureteric bud morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- lateral plasma membrane
- basal plasma membrane
- extracellular space
- extracellular vesicular exosome
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding