Ndufaf6 Gene Summary [Mouse]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 5 and nuclear type mitochondrial complex I deficiency 17. Orthologous to human NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufaf6 |
| Official Name | NADH:ubiquinone oxidoreductase complex assembly factor 6 [Source:MGI Symbol;Acc:MGI:1924197] |
| Ensembl ID | ENSMUSG00000050323 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase complex assembly factor 6 |
| Synonyms | 2310030N02Rik, C8orf38, FRTS5, HSALNG0067060, HSALNG0067063, lnc-INTS8-1, LOC101927002, MC1DN17, NADH:ubiquinone oxidoreductase complex assembly factor 6, NONHSAG050800, NONHSAG050801, NONHSAG050802, NONHSAG050804, RGD1309085, RP11 347C183, RP11-347C18.3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufaf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isoprenoid Biosynthesis enzymes, Class 1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- coronary artery disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- neoplasia
- Alzheimer disease
- Fanconi renotubular syndrome type 5
- prostate cancer
- hereditary disorder
- psoriasis
role in cell
- phosphorylation in
- proliferation
- formation
- formation in
- binding in
- damage in
- progression in
- progression
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufaf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
- biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane