Sstr5 Gene Summary [Mouse]
Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Is expressed in brain; cochlea; cochlear duct epithelium; cochlear ganglion; and organ of Corti. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sstr5 |
| Official Name | somatostatin receptor 5 [Source:MGI Symbol;Acc:MGI:894282] |
| Ensembl ID | ENSMUSG00000050824 |
| Bio databases IDs | |
| Aliases | somatostatin receptor 5 |
| Synonyms | Smstr5, Somato, somatostatin receptor 5, SS-5-R, SST5, Sst5 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sstr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- intracellular domain
- somatostatin receptor
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Sstr5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- diarrhea
- cutaneous melanoma
- breast cancer
- advanced hepatocellular carcinoma
- anal cancer
- cervical cancer
role in cell
- expression in
- growth
- proliferation
- number
- migration
- cisplatin sensitivity
- abnormal morphology
- G1 phase
- cytokinesis in
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sstr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of cell proliferation
- cellular response to glucocorticoid stimulus
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- somatostatin receptor activity