Sstr1 Gene Summary [Mouse]
Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sstr1 |
| Official Name | somatostatin receptor 1 [Source:MGI Symbol;Acc:MGI:98327] |
| Ensembl ID | ENSMUSG00000035431 |
| Bio databases IDs | |
| Aliases | somatostatin receptor 1 |
| Synonyms | GpcrRNA, Smstr-1, somatostatin receptor 1, SRIF-2, SS-1-R, SST1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sstr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- protein homodimerization
- somatostatin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Sstr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- obesity
- Parkinson disease
- acromegaly
- adult solid tumor
- pancreatic cancer
- bronchial neuroendocrine tumor
- metastatic neuroendocrine tumor of pancreatic origin
- neuroendocrine gastroenteropancreatic tumor
role in cell
- proliferation
- G1 phase
- abnormal morphology
- S phase
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- subsynaptic membrane
- Cytoplasm
- cell surface
- perisynaptic region
- postsynaptic region
- cellular membrane
- vesicles
- perisomatic process
- Golgi stacks
- nerve ending
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sstr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- cellular response to estradiol stimulus
- forebrain development
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- cerebellum development
- spermatogenesis
- negative regulation of cell proliferation
- response to starvation
- glutamate receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- somatostatin receptor activity