Mafg Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult behavior; in utero embryonic development; and regulation of epidermal cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MAFG (MAF bZIP transcription factor G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mafg |
| Official Name | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) [Source:MGI Symbol;Acc:MGI:96911] |
| Ensembl ID | ENSMUSG00000051510 |
| Bio databases IDs | |
| Aliases | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) |
| Synonyms | C630022N07RIK, hMAF, MAF bZIP transcription factor G, MGC13090, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mafg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- bZIP
- identical protein binding
- basic region leucin zipper
- DNA binding
Pathways
Biological processes and signaling networks where the Mafg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- thrombocytopenia
- splenomegaly
- neurodegeneration
role in cell
- expression in
- activation in
- formation
- formation in
- proliferation
- quantity
- differentiation
- cisplatin sensitivity
- binding in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mafg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- in utero embryonic development
- positive regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- regulation of epidermal cell differentiation
- adult behavior
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity