Maff Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within in utero embryonic development; regulation of epidermal cell differentiation; and skeletal muscle cell differentiation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human MAFF (MAF bZIP transcription factor F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maff |
| Official Name | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) [Source:MGI Symbol;Acc:MGI:96910] |
| Ensembl ID | ENSMUSG00000042622 |
| Bio databases IDs | |
| Aliases | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
| Synonyms | hMafF, MAF bZIP transcription factor F, MAFF-like, U-MAF, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maff often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Maff gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- metastasis
- breast cancer
- hypoplasia
- non-insulin-dependent diabetes mellitus
- Huntington disease
- chronic periodontal disease
- primary myelofibrosis
role in cell
- expression in
- differentiation
- growth
- induction in
- invasion by
- translocation in
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maff gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- in utero embryonic development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of epidermal cell differentiation
- regulation of transcription from RNA polymerase II promoter
- parturition
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity