Tnfsf8 Gene Summary [Mouse]
Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space and membrane. Is expressed in renal vasculature. Orthologous to human TNFSF8 (TNF superfamily member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf8 |
| Official Name | tumor necrosis factor (ligand) superfamily, member 8 [Source:MGI Symbol;Acc:MGI:88328] |
| Ensembl ID | ENSMUSG00000028362 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor (ligand) superfamily, member 8 |
| Synonyms | CD153, CD30L, CD30LG, TNF superfamily member 8, TNLG3A, tumor necrosis factor (ligand) superfamily, member 8, tumour necrosis factor (ligand) superfamily, member 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfsf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Tnfsf8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- Hodgkin disease
- soft tissue sarcoma cancer
- synovial sarcoma
- graft-vs-host disease
- psoriasiform dermatitis
- atopic dermatitis
- paroxysmal nocturnal hemoglobinuria
- hypereosinophilia
role in cell
- production in
- activation in
- number
- proliferation
- differentiation
- survival
- maturation
- cytostasis
- cellular infiltration by
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfsf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- immune response
- signal transduction
- CD8-positive, alpha-beta T cell differentiation
- cell-cell signaling
- positive regulation of transcription from RNA polymerase II promoter
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding