Opa3 Gene Summary [Mouse]
Acts upstream of or within several processes, including bone development; fat cell differentiation; and neuromuscular process. Located in mitochondrion. Is expressed in several structures, including eye; jaw; musculoskeletal system; optic nerve; and salivary gland. Used to study 3-methylglutaconic aciduria type 3. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opa3 |
| Official Name | optic atrophy 3 [Source:MGI Symbol;Acc:MGI:2686271] |
| Ensembl ID | ENSMUSG00000052214 |
| Bio databases IDs | |
| Aliases | optic atrophy 3 |
| Synonyms | D630048P19Rik, Gm1425, Gm472, MGA3, NEWGENE 1309147, optic atrophy 3, outer mitochondrial membrane lipid metabolism regulator OPA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Optic atrophy 3 protein (OPA3)
- outer mitochondrial membrane signal anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- 3-methylglutaconic aciduria type 3
- autosomal dominant optic atrophy 3
- Alzheimer disease
- alcoholism
- achromatopsia
regulates
- F Actin
- lipid
role in cell
- differentiation
- fragmentation
- fragmentation in
- rearrangement
- migration
- elongation
- rearrangement in
- elongation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid metabolic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- mitochondrion