Opa3 Gene Summary [Mouse]
Acts upstream of or within several processes, including bone development; fat cell differentiation; and neuromuscular process. Located in mitochondrion. Is expressed in several structures, including eye; jaw; musculoskeletal system; optic nerve; and salivary gland. Used to study 3-methylglutaconic aciduria type 3. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opa3 |
| Official Name | optic atrophy 3 [Source:MGI Symbol;Acc:MGI:2686271] |
| Ensembl ID | ENSMUSG00000052214 |
| Bio databases IDs | |
| Aliases | optic atrophy 3 |
| Synonyms | D630048P19Rik, Gm1425, Gm472, MGA3, NEWGENE 1309147, optic atrophy 3, outer mitochondrial membrane lipid metabolism regulator OPA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Optic atrophy 3 protein (OPA3)
- outer mitochondrial membrane signal anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- F Actin
- lipid
disease
- 3-methylglutaconic aciduria type 3
- autosomal dominant optic atrophy 3
- Alzheimer disease
- alcoholism
- achromatopsia
phenotypes
- abnormal abdominal fat pad morphology
- abnormal blood homeostasis
- abnormal brown adipose tissue morphology
- abnormal epiphyseal plate morphology
- abnormal gait
- abnormal heart left ventricle morphology
- abnormal liver morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal mitochondrial physiology
- abnormal mitochondrion morphology
- abnormal optic nerve morphology
- abnormal phospholipid level
- abnormal pilomotor reflex
- abnormal retinal layer morphology
- abnormal retinal nerve fiber layer morphology
- abnormal ventricle myocardium morphology
- abnormal vision
- abnormal white adipose tissue morphology
- axon degeneration
- cardiac interstitial fibrosis
- decreased birth body size
- decreased body length
- decreased body surface temperature
- decreased body weight
- decreased circulating insulin-like growth factor I level
- decreased fat cell size
- decreased liver glycogen level
- decreased retinal ganglion cell number
- decreased total body fat amount
- decreased white adipose tissue amount
- dehydration
- dilated cardiomyopathy
- dilated heart left ventricle
- dilated heart right ventricle
- hunched posture
- hypoactivity
- increased brown adipose tissue amount
- increased liver triglyceride level
- increased liver weight
- macrovesicular hepatic steatosis
- postnatal growth retardation
- premature death
- preweaning lethality incomplete penetrance
- short snout
- thin interventricular septum
- thin retinal ganglion layer
- thin retinal inner plexiform layer
- thin retinal outer nuclear layer
- tremors
role in cell
- differentiation
- fragmentation
- fragmentation in
- rearrangement
- migration
- elongation
- rearrangement in
- elongation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid metabolic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- mitochondrion