Gpr17 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and receptor serine/threonine kinase binding activity. Acts upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be active in plasma membrane. Is expressed in central nervous system; gut; and male reproductive gland or organ. Orthologous to human GPR17 (G protein-coupled receptor 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr17 |
| Official Name | G protein-coupled receptor 17 [Source:MGI Symbol;Acc:MGI:3584514] |
| Ensembl ID | ENSMUSG00000052229 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 17 |
| Synonyms | AI853548, G protein-coupled receptor 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- idiopathic pulmonary fibrosis
role in cell
- proliferation
- expression in
- phosphorylation in
- growth
- apoptosis
- cell viability
- differentiation
- accumulation
- cisplatin sensitivity
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response to antigenic stimulus
- oligodendrocyte differentiation
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- receptor serine/threonine kinase binding
- chemokine receptor activity