Zfp622 Gene Summary [Mouse]
Predicted to enable preribosome binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including central nervous system; early conceptus; and neural retina. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zfp622 |
| Official Name | zinc finger protein 622 [Source:MGI Symbol;Acc:MGI:1289282] |
| Ensembl ID | ENSMUSG00000052253 |
| Bio databases IDs | |
| Aliases | zinc finger protein 622 |
| Synonyms | 1110033B05Rik, D15Ertd806e, LOC103690028, Zfp622, zinc finger protein 622, ZPR9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp622 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2H2 type zinc-finger (2 copies)
- Zinc-finger double-stranded RNA-binding
- ribonucleoprotein binding
- protein binding
- zinc finger domain
- Zinc-finger of C2H2 type
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- activation in
- apoptosis
- signaling in
- binding in
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp622 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- ribosomal large subunit biogenesis
- positive regulation of apoptotic process
- induction of apoptosis by oxidative stress
- positive regulation of kinase activity
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi apparatus
- nucleolus
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding