Cebpe Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within macrophage differentiation; phagocytosis; and positive regulation of gene expression. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in bone marrow; liver; lung; and spleen. Human ortholog(s) of this gene implicated in immunodeficiency 108. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cebpe |
| Official Name | CCAAT/enhancer binding protein (C/EBP), epsilon [Source:MGI Symbol;Acc:MGI:103572] |
| Ensembl ID | ENSMUSG00000052435 |
| Bio databases IDs | |
| Aliases | CCAAT/enhancer binding protein (C/EBP), epsilon |
| Synonyms | CCAAT enhancer binding protein epsilon, CCAAT/enhancer binding protein epsilon, CCAAT enhancer binding protein ε, CCAAT/enhancer binding protein ε, C/EBPe, C/EBP-epsilon, C/EBP-ε, C/EPBe, CRP1, Gm294, IMD108, SGD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cebpe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- threonine phosphorylation site
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- binding protein
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Cebpe gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- precursor B-cell acute lymphoblastic leukemia
- specific granule deficiency 1
- acute lymphoblastic leukemia
- rhinitis
- immunodeficiency 108 with autoinflammation
- conjunctivitis
- osteomyelitis
- pleurisy
- specific granule deficiency
role in cell
- expression in
- killing
- migration
- maturation
- differentiation
- apoptosis
- proliferation
- growth
- transactivation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cebpe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- transcription, DNA-dependent
- positive regulation of gene expression
- myeloid cell differentiation
- phagocytosis
- granulocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- defense response
- macrophage differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity