Mcm6 Gene Summary [Mouse]
Contributes to DNA helicase activity and single-stranded DNA binding activity. Acts upstream of or within DNA replication. Located in nucleus. Part of MCM complex. Is expressed in several structures, including brain; eye; future brain; genitourinary system; and limb. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm6 |
| Official Name | minichromosome maintenance complex component 6 [Source:MGI Symbol;Acc:MGI:1298227] |
| Ensembl ID | ENSMUSG00000026355 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 6 |
| Synonyms | ASP-l1, D1Wsu22e, KI-MCM6, MCG40308, Mcmd6, minichromosome maintenance complex component 6, Mis5, MM6, P105MCM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MCM6 C-terminal winged-helix domain
- MCM P-loop domain
- enzyme
- protein binding
- identical protein binding
- MCM AAA-lid domain
- DNA helicase
- MCM helicase family
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- single-stranded DNA binding
- MCM N-terminal domain
Pathways
Biological processes and signaling networks where the Mcm6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- metastasis
- advanced cancer
- cancer
- morbid obesity
- epileptic seizure
- plexiform neurofibroma
- lactase persistence
- obesity
role in cell
- proliferation
- apoptosis
- migration
- growth
- phosphorylation in
- cell death
- quantity
- number
- colony formation by
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- chromatin fraction
- cell surface
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- double-strand break repair via break-induced replication
- regulation of DNA-dependent DNA replication initiation
- DNA replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- CMG complex
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- DNA helicase activity
- protein binding
- single-stranded DNA binding