Rnf103 Gene Summary [Mouse]
This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Details
| Type | Protein Coding |
| Official Symbol | Rnf103 |
| Official Name | ring finger protein 103 [Source:MGI Symbol;Acc:MGI:109483] |
| Ensembl ID | ENSMUSG00000052656 |
| Bio databases IDs | |
| Aliases | ring finger protein 103 |
| Synonyms | Adrg34, HKF-1, KF-1, ring finger protein 103, ZFP-103 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf103 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- tail domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
- Anaphase-promoting complex subunit 11 RING-H2 finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf103 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding