Cops2 Gene Summary [Mouse]
Enables transcription corepressor activity. Acts upstream of or within blastocyst growth; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops2 |
| Official Name | COP9 signalosome subunit 2 [Source:MGI Symbol;Acc:MGI:1330276] |
| Ensembl ID | ENSMUSG00000027206 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 2 |
| Synonyms | ALIEN, COP9 signalosome subunit 2, CSN2, SGN2, TRIP-15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- transcription co-repressor
- protein binding
Pathways
Biological processes and signaling networks where the Cops2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian neoplasm
- ovarian neoplasia
- hyperinsulinism
- mammary neoplasm
- non-insulin-dependent diabetes mellitus
- colon neoplasm
- colorectal neoplasia
- lung neoplasm
- thyroid gland neoplasm
role in cell
- activation in
- proliferation
- expression in
- differentiation
- G1/S phase transition
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- neuron differentiation
- signal transduction
- inner cell mass cell proliferation
- trophectodermal cell proliferation
- transcription from RNA polymerase II promoter
- protein neddylation
- protein deneddylation
- protein phosphorylation
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity