Best2 Gene Summary [Mouse]
Enables bicarbonate channel activity. Contributes to chloride channel activity. Involved in several processes, including bicarbonate transport; chloride transmembrane transport; and sensory perception of smell. Acts upstream of or within chloride transport. Located in basolateral plasma membrane and cilium. Part of chloride channel complex. Is expressed in ovary; submandibular gland; testis; and thymus. Orthologous to human BEST2 (bestrophin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Best2 |
| Official Name | bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588] |
| Ensembl ID | ENSMUSG00000052819 |
| Bio databases IDs | |
| Aliases | bestrophin 2 |
| Synonyms | bestrophin 2, VMD2L1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Best2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- anion channel
- channel/pore class transporter
- chloride channel
- intracellular ligand-gated ion channel
- ligand-gated ion channel
- protein binding
- Bestrophin, RFP-TM, chloride channel
- ion channel
- cation channel
- bicarbonate transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Best2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of smell
- membrane depolarization
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- cilium
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- intracellular ligand-gated ion channel activity
- protein binding
- metal ion binding
- chloride channel activity