Arhgef7 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including genitourinary system; liver; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef7 |
| Official Name | Rho guanine nucleotide exchange factor (GEF7) [Source:MGI Symbol;Acc:MGI:1860493] |
| Ensembl ID | ENSMUSG00000031511 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF7) |
| Synonyms | ARHG7, beta1PIX, BETA-PIX, betaPix-b, betaPix-c, Beta-Pix Cool, Cool, COOL-1, mKIAA0142, Nbla10314, P50, P50BP, P85, P85 beta pix, P85COOL1, P85SPR, P85 β pix, PAK3, Pak3bp, PAK-INTERACTING EXCHANGE FACTOR beta, PAK-INTERACTING EXCHANGE FACTOR β, PIX, PIXB, Rho guanine nucleotide exchange factor, Rho guanine nucleotide exchange factor 7, β-PIX, β Pix-a, β-Pix Cool |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured region two on RhoGEF 6 and 7
- leucine zipper domain
- betaPIX coiled coil
- Arf-GAP domain
- proline rich domain
- PH domain
- Dbl homology domain
- GTP binding domain
- dimerization domain
- protein kinase binding
- Calponin homology domain
- enzyme binding
- glutamic acid-rich domain
- protein binding
- Pleckstrin homology-like domain
- T1 domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- gamma-tubulin binding
- RhoGEF
- histidine-rich region
- guanyl-nucleotide exchange factor
- Unstructured region one on RhoGEF 6 and 7
- calponin homology (CH) domain superfamily
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Arhgef7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Axonal Guidance Signaling
- Breast Cancer Regulation by Stathmin1
- FAK Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- Reelin Signaling in Neurons
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- nonsyndromic X-linked mental retardation
- breast carcinoma
- growth failure
- epileptic seizure
- Huntington disease
- primary myelofibrosis
role in cell
- chemotaxis
- phosphorylation in
- formation
- formation in
- apoptosis
- migration
- quantity
- expression in
- binding in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- membrane fraction
- synaptosomal membrane fractions
- cell periphery
- apical compartment
- postsynaptic region
- focal adhesions
- Nucleus
- vacuole
- Plasma Membrane
- centrosome
- cytosol
- membrane ruffles
- spindle pole
- growth cone
- neurites
- synaptosomes
- synapse
- cytoplasmic vesicles
- perikaryon
- lamellipodia
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium morphogenesis
- signal transduction
- Golgi organization
- nervous system development
- positive regulation of substrate adhesion-dependent cell spreading
- Rho protein signal transduction
- positive regulation of GTPase activity
- positive regulation of apoptotic process
- ephrin receptor signaling pathway
- lamellipodium assembly
- focal adhesion assembly
- positive regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- centrosome
- focal adhesion
- cytoplasm
- cell cortex
- ruffle
- cytosol
- macromolecular complex
- neuronal cell body
- neuron projection
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- guanyl-nucleotide exchange factor activity
- gamma-tubulin binding