Efna5 Gene Summary [Mouse]
Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efna5 |
| Official Name | ephrin A5 [Source:MGI Symbol;Acc:MGI:107444] |
| Ensembl ID | ENSMUSG00000048915 |
| Bio databases IDs | |
| Aliases | ephrin A5 |
| Synonyms | AF1, AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, EPLG7, GLC1M, LERK-7, RAGS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efna5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Ephrin
- Cupredoxin superfamily
- chemorepellant
- ephrin receptor binding
- protein binding
- neurotrophin TRKB receptor binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Efna5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- gestational diabetes mellitus
- idiopathic pulmonary fibrosis
- insomnia
- schizophrenia
- epithelial cancer
- Alzheimer disease
- post-traumatic stress disorder
- bleeding
- hippocampal atrophy
role in cell
- proliferation
- cell viability
- expression in
- phosphorylation in
- binding in
- survival
- signaling in
- migration
- cell rounding
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- detergent resistant lipid raft fraction
- dendrite tip
- cell surface
- cell periphery
- cellular membrane
- plasma membrane extracellular face
- synapse
- perikaryon
- cell-cell adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efna5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- negative chemotaxis
- retinal ganglion cell axon guidance
- regulation of microtubule cytoskeleton organization
- regulation of cell morphogenesis
- regulation of cell-cell adhesion
- negative regulation of substrate adhesion-dependent cell spreading
- nervous system development
- axon guidance
- collateral sprouting
- cellular response to follicle-stimulating hormone stimulus
- positive regulation of collateral sprouting
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- regulation of GTPase activity
- positive regulation of protein phosphorylation
- ephrin receptor signaling pathway
- apoptotic process
- positive regulation of synapse assembly
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- caveola
- basement membrane
- adherens junction
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotrophin TRKC receptor binding
- protein binding
- ephrin receptor binding
- transmembrane receptor protein tyrosine kinase activator activity
- chemorepellent activity
- neurotrophin TRKB receptor binding
- neurotrophin TRKA receptor binding