Ggcx Gene Summary [Mouse]
Enables gamma-glutamyl carboxylase activity. Involved in several processes, including negative regulation of neurotransmitter secretion; negative regulation of testosterone biosynthetic process; and peptidyl-glutamic acid carboxylation. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of bone development; and type B pancreatic cell proliferation. Is active in endoplasmic reticulum lumen. Is expressed in liver. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ggcx |
| Official Name | gamma-glutamyl carboxylase [Source:MGI Symbol;Acc:MGI:1927655] |
| Ensembl ID | ENSMUSG00000053460 |
| Bio databases IDs | |
| Aliases | gamma-glutamyl carboxylase |
| Synonyms | Gamma Carboxylase, gamma-glutamyl carboxylase, LOC100507238, VKCFD1, γ Carboxylase, γ-glutamyl carboxylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ggcx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin binding
- Vitamin K-dependent gamma-carboxylase
- enzyme
- gamma-glutamyl carboxylase
- DoxX-like family
- Horizontally Transferred TransMembrane Domain
- RmlC-like cupin superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- organismal death
- pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
- prostate cancer
- combined deficiency of vitamin K-dependent clotting factors type 1
- angina pectoris
- coronary artery disease
- myocardial infarction
- abdominal hemorrhage
role in cell
- carboxylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ggcx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- vitamin K metabolic process
- peptidyl-glutamic acid carboxylation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- gamma-glutamyl carboxylase activity
- vitamin binding