Rdh8 Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within retinol metabolic process and visual perception. Predicted to be active in cytosol. Is expressed in eye. Used to study age related macular degeneration 2. Orthologous to human RDH8 (retinol dehydrogenase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh8 |
| Official Name | retinol dehydrogenase 8 [Source:MGI Symbol;Acc:MGI:2685028] |
| Ensembl ID | ENSMUSG00000053773 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 8 |
| Synonyms | Gm182, LOC687099, PRRDH, Retinol dehydrogenase 8, SDR28C2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- sepiapterin reductase
- retinol dehydrogenase
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- mir-122 (includes others)
disease
- retinopathy
- choroidal neovascularization
- cone-rod dystrophy
- retinal degeneration
- systemic lupus erythematosus
role in cell
- activation
- abnormal morphology
- invasion
- number
- electrophysiology
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- retinol metabolic process
- steroid biosynthetic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- retinol dehydrogenase activity
- NADP-retinol dehydrogenase activity