Ccl4 Gene Summary [Mouse]
Predicted to enable chemokine receptor binding activity and identical protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Located in extracellular space. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL4 (C-C motif chemokine ligand 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl4 |
| Official Name | chemokine (C-C motif) ligand 4 [Source:MGI Symbol;Acc:MGI:98261] |
| Ensembl ID | ENSMUSG00000018930 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 4 |
| Synonyms | Act-2, AT744.1, C-C motif chemokine ligand 4, MIP-1B, Mip1 β, Scya4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the Ccl4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- CCR5 Signaling in Macrophages
- Chemokine Signaling
- Communication between Innate and Adaptive Immune Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Pathogenesis of Multiple Sclerosis
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17F in Allergic Inflammatory Airway Diseases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypersensitive reaction
- insulin-dependent diabetes mellitus
- Sjögren syndrome
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- adjuvant arthritis
- crescentic glomerulonephritis
- amyloidosis
role in cell
- proliferation
- migration
- quantity
- recruitment
- chemotaxis
- response by
- cellular infiltration by
- trafficking
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space