Nbea Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and synapse organization. Acts upstream of or within hematopoietic stem cell homeostasis and protein localization. Located in several cellular components, including cytosol; nucleus; and trans-Golgi network. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; gut; neural tube; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NBEA (neurobeachin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nbea |
| Official Name | neurobeachin [Source:MGI Symbol;Acc:MGI:1347075] |
| Ensembl ID | ENSMUSG00000027799 |
| Bio databases IDs | |
| Aliases | neurobeachin |
| Synonyms | BCL8B, LYST2, mKIAA1544, NEDEGE, NEUROBEACHIN, RGD1562629 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nbea often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- protein kinase binding
- Neurobeachin-like, DUF1088
- Neurobeachin/BDCP, DUF4704 alpha solenoid region
- Neurobeachin beta propeller domain
- WD domain, G-beta repeat
- WD40
- Pleckstrin homology-like domain
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neurodevelopmental disorder with or without early-onset generalized epilepsy
- neurodevelopmental disorder with early-onset generalized epilepsy
- hereditary disorder
- Huntington disease
- human immunodeficiency virus I infection
- glioblastoma
- glioblastoma cancer
- refractive error
- cerebellar, ocular, craniofacial and genital syndrome
role in cell
- expression in
- synaptic transmission
- organization
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endomembrane system
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- trans Golgi network
- nucleoplasm
- synapse
- recycling endosomes
- sorting endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nbea gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- cytosol
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding