Pde5a Gene Summary [Mouse]
Enables 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in positive regulation of MAP kinase activity; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within several processes, including cGMP catabolic process; positive regulation of oocyte development; and regulation of nitric oxide mediated signal transduction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde5a |
| Official Name | phosphodiesterase 5A, cGMP-specific [Source:MGI Symbol;Acc:MGI:2651499] |
| Ensembl ID | ENSMUSG00000053965 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 5A, cGMP-specific |
| Synonyms | CGB-PDE, cGMP phosphodiesterase, CN5A, Cn5n, PDE5, PDE5A1, PDE5A2, PDE V, Phosphodiesterase 5, phosphodiesterase 5A, phosphodiesterase 5A, cGMP-specific |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cyclic-nucleotide phosphodiesterase
- regulatory domain
- 3',5'-cyclic-GMP phosphodiesterase
- GAF domain
- enzyme
- protein binding
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
- 3',5'-cGMP binding
- Domain present in phytochromes and cGMP-specific phosphodiesterases
Pathways
Biological processes and signaling networks where the Pde5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- liver disease
- vomiting
- pulmonary hypertension
- pulmonary hypertensive arterial disease
- impotence
- heart failure
- asthma
- intrauterine growth retardation
- impaired glucose tolerance
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- production in
- development
- transdifferentiation
- migration
- hypertrophy
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- Z line
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of oocyte development
- oocyte development
- cGMP catabolic process
- regulation of nitric oxide mediated signal transduction
- negative regulation of T cell proliferation
- T cell proliferation
- positive regulation of cardiac muscle hypertrophy
- negative regulation of cardiac muscle contraction
- cAMP-mediated signaling
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- cGMP binding
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity