Atpif1 Gene Summary [Mouse]
This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse cancer cells, while high expression levels of this gene have been correlated with gastric and liver cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Atpif1 |
| Official Name | ATPase inhibitory factor 1 [Source:MGI Symbol;Acc:MGI:1196457] |
| Ensembl ID | ENSMUSG00000054428 |
| Bio databases IDs | |
| Aliases | ATPase inhibitory factor 1 |
| Synonyms | Atpase inhibitor (mitochondrial if1 protein), ATPI, ATPIF1, ATPIP, ATP synthase inhibitory factor subunit 1, IF1, IF(1), IF1PA, IP, Urinary protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atpif1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- binding protein
- calmodulin binding
- ATPase inhibitor activity
- enzyme inhibitor activity
- enzyme binding
- Mitochondrial ATPase inhibitor, IATP
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- obesity
- non-small cell lung adenosquamous carcinoma
- lung adenosquamous cancer
- Huntington disease
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- proliferation
- hyperpolarization
- phosphorylation in
- generation in
- accumulation in
- number
- degradation in
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atpif1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- negative regulation of hydrolase activity
- mitochondrial depolarization
- generation of precursor metabolites and energy
- erythrocyte differentiation
- negative regulation of ATPase activity
- angiogenesis
- heme biosynthetic process
- negative regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- macromolecular complex
- cell surface
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- protein binding
- enzyme inhibitor activity
- ATPase inhibitor activity
- angiostatin binding
- enzyme binding
- ATPase binding