Srl Gene Summary [Mouse]
Predicted to enable GTP binding activity. Acts upstream of or within response to muscle activity involved in regulation of muscle adaptation and store-operated calcium entry. Predicted to be located in sarcoplasmic reticulum lumen and sarcoplasmic reticulum membrane. Is expressed in brain ventricular layer; diaphragm; limb; skeletal musculature; and tail mesenchyme. Orthologous to human SRL (sarcalumenin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srl |
| Official Name | sarcalumenin [Source:MGI Symbol;Acc:MGI:2146620] |
| Ensembl ID | ENSMUSG00000022519 |
| Bio databases IDs | |
| Aliases | sarcalumenin |
| Synonyms | 9830004M20Rik, SAR, Sarcalumenin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 50S ribosome-binding GTPase
- protein binding
- N-terminal EH-domain containing protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcoplasmic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srl gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum lumen
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding