Cggbp1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor binding activity; double-stranded DNA binding activity; and identical protein binding activity. Predicted to be involved in epigenetic regulation of gene expression and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo; inner ear; and otocyst. Orthologous to human CGGBP1 (CGG triplet repeat binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cggbp1 |
| Official Name | CGG triplet repeat binding protein 1 [Source:MGI Symbol;Acc:MGI:2146370] |
| Ensembl ID | ENSMUSG00000054604 |
| Bio databases IDs | |
| Aliases | CGG triplet repeat binding protein 1 |
| Synonyms | AL357195, CGBP1, CGGBP, CGG triplet repeat binding protein 1, p20-CGGBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cggbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- major depression
regulated by
- cisplatin
- tretinoin
- dexamethasone
- Dengue virus 2 Thailand/NGS-C/1944
role in cell
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cggbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of gene expression
- regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- double-stranded DNA binding