Spast Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; microtubule severing ATPase activity; and tubulin binding activity. Involved in anterograde axonal transport and axonal transport of mitochondrion. Acts upstream of or within microtubule severing. Located in microtubule cytoskeleton and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spast |
| Official Name | spastin [Source:MGI Symbol;Acc:MGI:1858896] |
| Ensembl ID | ENSMUSG00000024068 |
| Bio databases IDs | |
| Aliases | spastin |
| Synonyms | ADPSP, FSP2, mKIAA1083, SPASTIN, SPG4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spast often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- microtubule binding domain
- RXXs motif
- MIT
- nuclear localization sequence
- MIT domain
- enzyme
- protein binding
- AAA+ lid domain
- microtubule-severing ATPase
- Microtubule Interacting and Trafficking molecule domain
- AAA domain (dynein-related subfamily)
- microtubule binding
- MIT (microtubule interacting and transport) domain
- ATPase family associated with various cellular activities (AAA)
- binding protein
- ATPase domain
- alpha-tubulin binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- hydrophobic domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- autosomal dominant spastic paraplegia type 4
- hereditary spastic paraplegia
- hereditary disorder
- polycystic ovary syndrome
- spastic paraparesis
- spastic paraplegia
- gait disturbance
- infertility condition
- hereditary spastic paraplegia X-linked
role in cell
- growth
- growth in
- proliferation
- number
- formation
- binding
- morphology
- branching
- axonal transport
- severing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- endoplasmic reticulum tubules
- constriction sites
- Cytoplasm
- perinuclear region
- endosomes
- centrosome
- Endoplasmic Reticulum
- midbody
- asters
- cytosol
- nucleoplasm
- spindle pole
- nuclear envelope
- neurites
- cytoplasmic vesicles
- perikaryon
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spast gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic nuclear envelope reassembly
- membrane fission
- anterograde axon cargo transport
- protein homooligomerization
- cytokinetic process
- microtubule severing
- ER to Golgi vesicle-mediated transport
- microtubule bundle formation
- axonogenesis
- cytokinesis after mitosis
- protein hexamerization
- axon transport of mitochondrion
- exit from mitosis
- nuclear envelope reassembly
- mitotic spindle disassembly
- positive regulation of microtubule depolymerization
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- spindle pole
- endoplasmic reticulum
- nucleoplasm
- microtubule
- endoplasmic reticulum membrane
- lipid particle
- nucleus
- nuclear membrane
- centrosome
- perinuclear region of cytoplasm
- endosome
- extracellular vesicular exosome
- cytoplasm
- cytosol
- cytoplasmic vesicle
- midbody
- axon
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- beta-tubulin binding
- alpha-tubulin binding
- microtubule-severing ATPase activity
- microtubule binding
- isomerase activity