Wasf1 Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium and mitochondrial outer membrane. Is active in postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wasf1 |
| Official Name | WASP family, member 1 [Source:MGI Symbol;Acc:MGI:1890563] |
| Ensembl ID | ENSMUSG00000019831 |
| Bio databases IDs | |
| Aliases | WASP family, member 1 |
| Synonyms | NEDALVS, Scar, SCAR1, WASP family member 1, WASP family, member 1, WAVE, WAVE-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wasf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wiskott Aldrich syndrome homology region 2
- protein kinase A binding
- VCA domain
- SHD domain
- enzyme binding
- central domain
- leucine zipper domain
- protein binding
- V domain
- proline rich domain
- acidic domain
- WH2 motif
- Scar/WAVE homology domain
- WRP binding domain
- verprolin homology domain
- WA domain
- WH2
- basic domain
Pathways
Biological processes and signaling networks where the Wasf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimer disease
- neurodevelopmental disorder with absent language and variable seizures
- mental retardation
- small cell lung cancer
- memory deficits
- infection by Human enterovirus 71
role in cell
- quantity
- cell death
- number
- morphogenesis
- migration
- formation
- transport
- morphology
- ruffling
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoskeleton
- Cytoplasm
- postsynaptic region
- actin cytoskeleton
- Golgi Apparatus
- Mitochondria
- cytosol
- membrane ruffles
- mitochondrial outer membrane
- synaptic vesicles
- neurites
- synaptosomes
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wasf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- positive regulation of nerve growth factor receptor signaling pathway
- macromolecular complex assembly
- lamellipodium morphogenesis
- actin filament polymerization
- positive regulation of Arp2/3 complex-mediated actin nucleation
- receptor-mediated endocytosis
- actin cytoskeleton organization
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- cytoskeleton
- focal adhesion
- actin cytoskeleton
- cytosol
- macromolecular complex
- mitochondrial outer membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- protein kinase A regulatory subunit binding
- small GTPase binding
- protein kinase A binding
- Arp2/3 complex binding