Nabp2 Gene Summary [Mouse]
Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Involved in DNA repair and positive regulation of telomere capping. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nabp2 |
| Official Name | nucleic acid binding protein 2 [Source:MGI Symbol;Acc:MGI:1917167] |
| Ensembl ID | ENSMUSG00000025374 |
| Bio databases IDs | |
| Aliases | nucleic acid binding protein 2 |
| Synonyms | 2610036N15Rik, hSSB1, nucleic acid binding protein 2, OBFC2B, RGD1308158, SOSS-B1, SSB1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nabp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- OB-fold nucleic acid binding domain
- single-stranded DNA binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- telomeric DNA binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cleft palate
- liver cancer
- dyspnea
- hepatocellular carcinoma
- organismal death
- hypoplasia
- chromosomal instability
- growth failure
- micrognathia
role in cell
- apoptosis
- proliferation
- cell viability
- loss
- number
- migration
- DNA damage response
- G2/M phase
- abnormal morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nabp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of telomerase activity
- DNA repair
- mitotic cell cycle checkpoint
- establishment of protein localization to telomere
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- cytosol
- SOSS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA polymerase binding
- protein binding
- single-stranded DNA binding