Wls Gene Summary [Mouse]
Enables Wnt-protein binding activity. Involved in several processes, including brain development; cementum mineralization; and exocrine pancreas development. Acts upstream of or within Wnt protein secretion. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skin. Used to study Zaki syndrome. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wls |
| Official Name | wntless WNT ligand secretion mediator [Source:MGI Symbol;Acc:MGI:1915401] |
| Ensembl ID | ENSMUSG00000028173 |
| Bio databases IDs | |
| Aliases | wntless WNT ligand secretion mediator |
| Synonyms | 5031439A09Rik, C1orf139, EVI, FLJ23091, GPR177, LOC108350151, LOC362065, mig-14, MRP, wntless WNT ligand secretion mediator, Wnt ligand secretion mediator, ZKS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wls often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- Wnt-binding factor required for Wnt secretion
- G-protein-coupled receptor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- metastatic colorectal cancer
- osteoporosis
- tumorigenesis
- psoriasis
- Zaki syndrome
- flushing response
- androgenic alopecia
- alopecia
role in cell
- activation in
- expression in
- proliferation
- number
- cellular infiltration by
- production in
- positioning
- differentiation
- self-renewal
- depletion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- dendrites
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wls gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cementum mineralization
- Wnt protein secretion
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of Wnt protein secretion
- intracellular protein transport
- anterior/posterior axis specification
- midbrain development
- hindbrain development
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- mesoderm formation
- exocrine pancreas development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- organelle membrane
- plasma membrane
- early endosome membrane
- endoplasmic reticulum membrane
- trans-Golgi network
- early endosome
- extracellular vesicular exosome
- cytoplasmic vesicle
- cytosol
- endomembrane system
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- Wnt-protein binding