Cbx6 Gene Summary [Mouse]
Enables single-stranded RNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and intestine smooth muscle circular layer. Orthologous to human CBX6 (chromobox 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx6 |
| Official Name | chromobox 6 [Source:MGI Symbol;Acc:MGI:3512628] |
| Ensembl ID | ENSMUSG00000089715 |
| Bio databases IDs | |
| Aliases | chromobox 6 |
| Synonyms | chromobox 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- CBX family C-terminal motif
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- protein binding
- single-stranded RNA binding
- Chromo (CHRromatin organization MOdifier) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- organismal death
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- adenomyosis
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- nuclear body
- PRC1 complex
- PcG protein complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding
- single-stranded RNA binding
- chromatin binding