Map6 Gene Summary [Mouse]
Enables microtubule binding activity. Predicted to be involved in several processes, including axonal transport of mitochondrion; dendrite morphogenesis; and positive regulation of axonogenesis. Predicted to be located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including Golgi-associated vesicle; cis-Golgi network; and microtubule. Is expressed in cortical plate; cranial ganglion; dorsal root ganglion; and sensory organ. Used to study schizophrenia. Orthologous to human MAP6 (microtubule associated protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map6 |
| Official Name | microtubule-associated protein 6 [Source:MGI Symbol;Acc:MGI:1201690] |
| Ensembl ID | ENSMUSG00000055407 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 6 |
| Synonyms | 2810411E12Rik, KIAA1878, MAP6-N, microtubule-associated protein 6, MTAP6, N-STOP, STOP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mc module
- microtubule binding
- protein binding
- Mn module
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- preeclampsia
- acute myeloid leukemia
role in cell
- formation
- quantity
- transport
- stability
- morphogenesis
- stabilization
- organization
- localization
- axonal transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- insoluble fractions
- perinuclear region
- Golgi Apparatus
- microtubules
- dendritic spines
- neurites
- secretory vesicles
- perikaryon
- axons
- dendrites
- microspikes
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- positive regulation of axonogenesis
- regulation of microtubule cytoskeleton organization
- cytoskeleton-dependent intracellular transport
- microtubule cytoskeleton organization
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- cis-Golgi network
- transport vesicle membrane
- perinuclear region of cytoplasm
- Golgi-associated vesicle
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- microtubule binding