MAP6 Gene Summary [Human]

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
MAP6
Official Name
microtubule associated protein 6 [Source:HGNC Symbol;Acc:HGNC:6868]
Ensembl ID
ENSG00000171533
Bio databases IDs NCBI: 4135 Ensembl: ENSG00000171533
Aliases microtubule associated protein 6
Synonyms 2810411E12Rik, KIAA1878, MAP6-N, microtubule-associated protein 6, MTAP6, N-STOP, STOP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mc module
  • microtubule binding
  • protein binding
  • Mn module

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • COVID-19
  • preeclampsia
  • acute myeloid leukemia
regulated by
role in cell
  • formation
  • quantity
  • transport
  • stability
  • morphogenesis
  • stabilization
  • organization
  • localization
  • axonal transport

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • soluble fraction
  • insoluble fractions
  • perinuclear region
  • Golgi Apparatus
  • microtubules
  • dendritic spines
  • neurites
  • secretory vesicles
  • perikaryon
  • axons
  • dendrites
  • microspikes
  • synaptosomal fractions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MAP6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lysosome localization
  • positive regulation of axonogenesis
  • regulation of microtubule cytoskeleton organization
  • cytoskeleton-dependent intracellular transport
  • microtubule cytoskeleton organization
  • dendrite morphogenesis

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • cis-Golgi network
  • transport vesicle membrane
  • perinuclear region of cytoplasm
  • Golgi-associated vesicle
  • axon
  • microtubule

Molecular Function

What the gene product does at the molecular level
  • calmodulin binding
  • protein binding
  • microtubule binding

Gene-Specific Assays for Results You Can Trust

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