St3gal5 Gene Summary [Mouse]
Predicted to enable lactosylceramide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; olfactory epithelium; and spleen. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal5 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Source:MGI Symbol;Acc:MGI:1339963] |
| Ensembl ID | ENSMUSG00000056091 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
| Synonyms | 3S-T, [a]2, alpha-2,3 SIALYLTRANSFERASE, GM3S, GM3 SYNTHASE, SATI, SIAT9, SIATGM3S, SPDRS, ST3 beta-galactoside alpha-2,3-sialyltransferase 5, ST3Gal V, ST3 β-galactoside α-2,3-sialyltransferase 5, α-2,3 SIALYLTRANSFERASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St3gal5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- sialyltransferase
- lactosylceramide alpha-2,3-sialyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Amish infantile epilepsy syndrome
- mental retardation
- paraparesis
- obesity
- non-insulin-dependent diabetes mellitus
- hyperactive behavior
- Huntington disease
- hypoglycemia
- astrocytosis
role in cell
- proliferation
- expression in
- differentiation
- phosphorylation in
- activation
- degeneration
- formation
- tumorigenicity
- motility
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St3gal5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein glycosylation
- glycosphingolipid biosynthetic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- lactosylceramide alpha-2,3-sialyltransferase activity