Cntrl Gene Summary [Mouse]
Acts upstream of or within circulatory system development; female germ-line stem cell asymmetric division; and kidney development. Located in meiotic spindle pole; mitotic spindle pole; and perinuclear region of cytoplasm. Is expressed in cerebral cortex ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Used to study nephronophthisis. Orthologous to human CNTRL (centriolin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntrl |
| Official Name | centriolin [Source:MGI Symbol;Acc:MGI:1889576] |
| Ensembl ID | ENSMUSG00000057110 |
| Bio databases IDs | |
| Aliases | centriolin |
| Synonyms | 6720467O09RIK, AA968343, b2b1468.1Clo, b2b1468Clo, bA165P4.1, CENTRIOLIN, CEP1, CEP110, FAN, IB3/5, MA2A8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cntrl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Synaptonemal complex protein 1 (SCP-1)
- Leucine rich repeat
- helix-rich Mycoplasma protein
- Domain of unknown function (DUF5082)
- Leucine Rich repeats (2 copies)
- chromosome segregation protein SMC, common bacterial type
- leucine-rich repeat
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- protein phosphatase 1 regulatory subunit 42
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Alpha helical coiled-coil rod protein (HCR)
- Domain of unknown function (DUF4686)
- RecF/RecN/SMC N terminal domain
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- spindle pole
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cntrl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- aorta development
- kidney development
- ventricular septum development
- coronary vasculature development
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- microtubule organizing center
- centriolar satellite
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding