Dph6 Gene Summary [Mouse]
Predicted to enable diphthine-ammonia ligase activity. Predicted to be involved in protein histidyl modification to diphthamide. Orthologous to human DPH6 (diphthamine biosynthesis 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dph6 |
| Official Name | diphthamine biosynthesis 6 [Source:MGI Symbol;Acc:MGI:1913882] |
| Ensembl ID | ENSMUSG00000057147 |
| Bio databases IDs | |
| Aliases | diphthamine biosynthesis 6 |
| Synonyms | 5730421E18Rik, ATPBD4, diphthamine biosynthesis 6, DKFZp313L0839, RGD1310006 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dph6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- diphthine-ammonia ligase
- MJ0570-related uncharacterized domain
- enzyme
- Adenine nucleotide alpha hydrolase (AANH) superfamily
Pathways
Biological processes and signaling networks where the Dph6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- metabolic syndrome X
phenotypes
- abnormal coat/hair pigmentation
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased Ly6C-positive mature NK cell number
- decreased NK T cell number
- decreased T-helper cell number
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased mature B cell number
- increased CD11b-low dendritic cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha beta T cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD5-positive gamma-delta T cell number
- increased KLRG1-positive CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased KLRG1-positive T-helper cell number
- increased dendritic cell number
- increased effector memory T-helper cell number
- increased gamma-delta T cell number
- increased granulocyte number
- increased marginal zone B cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker CD4-negative NK T cell number
- increased memory-marker gamma-delta T cell number
- increased monocyte cell number
- increased plasma cell number
- increased plasmacytoid dendritic cell number
- vertebral transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dph6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- diphthine-ammonia ligase activity