Morc1 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in negative regulation of gene expression and spermatogenesis. Acts upstream of or within behavioral fear response; epigenetic regulation of gene expression; and negative regulation of DNA-templated transcription initiation. Is active in male germ cell nucleus. Is expressed in esophagus; head mesenchyme; musculoskeletal system; sensory organ; and testis. Used to study melancholic depression. Orthologous to human MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Morc1 |
| Official Name | microrchidia 1 [Source:MGI Symbol;Acc:MGI:1316740] |
| Ensembl ID | ENSMUSG00000022652 |
| Bio databases IDs | |
| Aliases | microrchidia 1 |
| Synonyms | CT33, microrchidia 1, MORC, MORC family CW-type zinc finger 1, RGD1565610, ZCW6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Morc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CW-type Zinc Finger
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- Histidine kinase-like ATPase domain
- protein binding
- Morc6 ribosomal protein S5 domain 2-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- colorectal cancer
phenotypes
- abnormal apoptosis
- abnormal depression-related behavior
- arrest of male meiosis
- azoospermia
- decreased male germ cell number
- male infertility
- small testis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Morc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transposition, RNA-mediated
- spermatogenesis
- cell differentiation
- gene silencing by RNA
- negative regulation of transcription initiation, DNA-dependent
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- nucleus
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding