DPH6 Gene Summary [Human]
Enables diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | DPH6 |
| Official Name | diphthamine biosynthesis 6 [Source:HGNC Symbol;Acc:HGNC:30543] |
| Ensembl ID | ENSG00000134146 |
| Bio databases IDs | |
| Aliases | diphthamine biosynthesis 6, diphthine--ammonia ligase |
| Synonyms | 5730421E18Rik, ATPBD4, diphthamine biosynthesis 6, DKFZp313L0839, RGD1310006 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPH6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- diphthine-ammonia ligase
- MJ0570-related uncharacterized domain
- enzyme
- Adenine nucleotide alpha hydrolase (AANH) superfamily
Pathways
Biological processes and signaling networks where the DPH6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPH6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- diphthine-ammonia ligase activity