Rit2 Gene Summary [Mouse]
Enables several functions, including GTP binding activity; GTPase activity; and calmodulin binding activity. Involved in several processes, including Ras protein signal transduction; regulation of Cdc42 protein signal transduction; and regulation of neuron projection development. Located in several cellular components, including cell body; dendritic tree; and nucleus. Is expressed in central nervous system; lung; and neural retina. Orthologous to human RIT2 (Ras like without CAAX 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rit2 |
| Official Name | Ras-like without CAAX 2 [Source:MGI Symbol;Acc:MGI:108054] |
| Ensembl ID | ENSMUSG00000057455 |
| Bio databases IDs | |
| Aliases | Ras-like without CAAX 2 |
| Synonyms | Ras-like without CAAX 2, RIBA, RIN, Rit1, ROC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rit2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- calmodulin binding domain
- GTPase
- chromatin binding
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- GTP binding
- ADP-ribosylation factor family
- semaphorin receptor binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Parkinson disease
- side effect
- acute lymphoblastic leukemia
- idiopathic scoliosis
- infection by vesicular stomatitis virus
role in cell
- expression in
- differentiation
- phosphorylation in
- production in
- formation
- development
- outgrowth
- endocytosis by
- activation in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- neurites
- dendritic trees
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rit2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- synaptic transmission
- Ras protein signal transduction
- positive regulation of MAPK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- maintenance of protein location in cell
- MAPK cascade
- negative regulation of neuron projection development
- regulation of protein phosphorylation
- regulation of calcium-mediated signaling
- positive regulation of neuron projection development
- regulation of endocytosis
- regulation of Cdc42 protein signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane raft
- cell body
- cytosol
- Golgi apparatus
- synapse
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- calmodulin binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- chromatin binding
- semaphorin receptor binding