Sh3rf2 Gene Summary [Mouse]
Predicted to enable protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein autoubiquitination; regulation of JNK cascade; and regulation of protein metabolic process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Used to study autism spectrum disorder. Orthologous to human SH3RF2 (SH3 domain containing ring finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3rf2 |
| Official Name | SH3 domain containing ring finger 2 [Source:MGI Symbol;Acc:MGI:2444628] |
| Ensembl ID | ENSMUSG00000057719 |
| Bio databases IDs | |
| Aliases | SH3 domain containing ring finger 2 |
| Synonyms | 2310046K19, 9130023G24Rik, HEPP1, Posh2, POSHER, PPP1R39, RNF158, SH3 domain containing ring finger 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3rf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 binding
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- Src Homology 3 domain superfamily
- phosphatase binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- seizures
- tuberculosis
- growth failure
- acute myeloid leukemia
- bacteremia
- hyperactive behavior
role in cell
- apoptosis
- migration
- afterhyperpolarization
- colony formation by
- upregulation in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3rf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- negative regulation of protein ubiquitination
- negative regulation of JNK cascade
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein autoubiquitination
- protein ubiquitination
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein phosphatase inhibitor activity
- protein binding
- metal ion binding
- protein phosphatase 1 binding