Amotl2 Gene Summary [Mouse]
Enables actin filament binding activity and identical protein binding activity. Involved in endothelial cell morphogenesis. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including brain ventricular layer; dorsal aorta; gonad; telencephalon; and trophectoderm. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amotl2 |
| Official Name | angiomotin-like 2 [Source:MGI Symbol;Acc:MGI:1929286] |
| Ensembl ID | ENSMUSG00000032531 |
| Bio databases IDs | |
| Aliases | angiomotin-like 2 |
| Synonyms | angiomotin-like 2, LCCP, MASCOT, mKIAA0989 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amotl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- binding protein
- Angiomotin C terminal
- protein binding
- identical protein binding
- PPQY motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myopia
- refractive error
role in cell
- expression in
- growth
- phosphorylation in
- binding in
- proliferation
- activation in
- migration
- morphogenesis
- specification
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- podosomes
- Nucleus
- cytosol
- apical membrane
- cytoplasmic vesicles
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amotl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- Wnt receptor signaling pathway
- hippo signaling cascade
- regulation of cell migration
- establishment of cell polarity involved in ameboidal cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoplasmic vesicle
- cytosol
- recycling endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding