Megf6 Gene Summary [Mouse]

Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including embryo mesenchyme; head bone; intraembryonic coelom; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Megf6
Official Name
multiple EGF-like-domains 6 [Source:MGI Symbol;Acc:MGI:1919351]
Ensembl ID
ENSMUSG00000057751
Bio databases IDs NCBI: 230971 Ensembl: ENSMUSG00000057751
Aliases multiple EGF-like-domains 6
Synonyms 2600001P17Rik, EGFL3, LOC100911486, multiple EGF-like-domains 6
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Megf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Complement Clr-like EGF-like
  • EMI domain
  • protein binding
  • Coagulation Factor Xa inhibitory site
  • EGF_CA

Pathways

Biological processes and signaling networks where the Megf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • systemic mastocytosis
  • bladder exstrophy
regulated by
  • cisplatin
  • TMPRSS2-ERG
  • focal adhesion kinase
  • RGS4
  • capmatinib
  • ASXL3
  • BLM
  • molybdenum disulfide
  • MET
regulates
  • receptor protein tyrosine kinase

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Megf6 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • calcium ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.