Serpina3k Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Located in collagen-containing extracellular matrix. Is expressed in axial skeleton; liver; nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpina3k |
| Official Name | serine (or cysteine) peptidase inhibitor, clade A, member 3K [Source:MGI Symbol;Acc:MGI:98377] |
| Ensembl ID | ENSMUSG00000058207 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade A, member 3K |
| Synonyms | 1300001I07Rik, 1A1, 3e46, A3n, Alpha1-antitrypsin proteinase inhibitor, contrapsin, Contrapsin Like Protease Inhibitor Related, Contraspin-like protease inhibitor, CPi-26, D12Rp54, Eb22/5, Kalbp, Klkbp, MMCM2, MMCM7, MMSpi2, MMSPi2.4, RP54, serine (or cysteine) peptidase inhibitor, clade A, member 3C, serine (or cysteine) peptidase inhibitor, clade A, member 3K, serine (or cysteine) peptidase inhibitor, clade A, member 3M, serine (or cysteine) peptidase inhibitor, clade A, member 3N, Serine protease inhibitor, Serine Proteinase Inhibitor 2.4, Serpin3n, Serpina3, Serpina3c, Serpina3k, Serpina3m, serpin family A member 3N, SPI2, Spi-2.2, Spi2-2, Spi2.4, Spi2/eb.4, Spi-2l, Spi-2rs1, SPI3, Spin2c, Spin3 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpina3k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebral hemorrhage
- hepatic steatosis
- doxorubicin induced cardiotoxicity
- hepatic fibrosis
- experimentally-induced diabetes
- dextran sodium sulfate-induced colitis
- allodynia
- abnormal glomerular filtration rate
role in cell
- growth
- expression in
- proliferation
- apoptosis
- phosphorylation in
- cell death
- cellular infiltration by
- formation
- necroptosis
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma