Zfp516 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ZNF516 (zinc finger protein 516). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp516 |
| Official Name | zinc finger protein 516 [Source:MGI Symbol;Acc:MGI:2443957] |
| Ensembl ID | ENSMUSG00000058881 |
| Bio databases IDs | |
| Aliases | zinc finger protein 516 |
| Synonyms | C330029B10RIK, D230016L03, HsT287, mKIAA0222, RGD1306817, Zfp26l, ZFP516, zinc finger protein 516 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp516 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- open-angle glaucoma
- diverticular disease
- metabolic syndrome X
- refractive error
- early missed abortion
- prostate cancer
regulated by
- beta-estradiol
- AGT
- tretinoin
role in cell
- differentiation
- missegregation
- missegregation in
- stress response in
- structural deficit
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp516 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- response to cold
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity