Ifnl2 Gene Summary [Mouse]
Predicted to enable interleukin-28 receptor binding activity. Involved in defense response to virus and mucosal immune response. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifnl2 |
| Official Name | interferon lambda 2 [Source:MGI Symbol;Acc:MGI:3647279] |
| Ensembl ID | ENSMUSG00000059128 |
| Bio databases IDs | |
| Aliases | interferon lambda 2 |
| Synonyms | EG330496, If1ia1, If1ia2, IFL-1, Ifnl1, Ifnl2, Ifnl3, Ifn lambda2, Ifn lambda3, Il28, IL-28A, IL-28B, INF-alpha, INF-lambda, INF-α, INF-λ, interferon, lambda 1, interferon lambda 2, interferon lambda 3, interferon, lambda 3, interferon, λ 1, interferon λ 2, interferon λ 3, interferon, λ 3, LOC685861, LOC687396 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifnl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- receptor binding
- Interleukin-28A
Pathways
Biological processes and signaling networks where the Ifnl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- collagen-induced arthritis
- weight loss
- infection by human herpesvirus 2
role in cell
- expression in
- production in
- degranulation
- quantity
- expansion
- proliferation
- cross-priming
- replication in
- recruitment
- granularity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space