Nsmce2 Gene Summary [Mouse]
Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in brain; cerebral cortex ventricular layer; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsmce2 |
| Official Name | NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [Source:MGI Symbol;Acc:MGI:1915751] |
| Ensembl ID | ENSMUSG00000059586 |
| Bio databases IDs | |
| Aliases | NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase |
| Synonyms | 1110014D18Rik, C8orf36, MMS21, NSE2, NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, RGD1305156, ZMIZ7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsmce2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO transferase activity
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- enzyme
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsmce2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of maintenance of mitotic sister chromatid cohesion
- protein sumoylation
- cellular senescence
- double-strand break repair via homologous recombination
- positive regulation of mitotic metaphase/anaphase transition
- telomere maintenance via recombination
- double-strand break repair via nonhomologous end joining
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- nuclear body
- PML body
- Smc5-Smc6 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- SUMO ligase activity