Nsmce1 Gene Summary [Mouse]
Predicted to enable protein dimerization activity and ubiquitin protein ligase activity. Predicted to be involved in double-strand break repair via homologous recombination. Located in chromosome, centromeric region; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in cerebral cortex ventricular layer; cortical plate; and pancreas epithelium. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsmce1 |
| Official Name | NSE1 homolog, SMC5-SMC6 complex component [Source:MGI Symbol;Acc:MGI:1914961] |
| Ensembl ID | ENSMUSG00000030750 |
| Bio databases IDs | |
| Aliases | NSE1 homolog, SMC5-SMC6 complex component |
| Synonyms | 2510027N19Rik, NSE1, NSE1 homolog, SMC5-SMC6 complex component, RGD1307760 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsmce1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- protein kinase C conserved region 1 (C1 domain) superfamily
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Nse1 non-SMC component of SMC5-6 complex
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- peripheral arterial disease
- asthma
role in cell
- cell death
- cell survival
- camptothecin sensitivity
- cisplatin sensitivity
- DNA damage response
- methyl methanesulfonate sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- spindle pole
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsmce1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- intracellular membrane-bounded organelle
- Smc5-Smc6 complex
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- protein dimerization activity