Brd2 Gene Summary [Mouse]
Enables lysine-acetylated histone binding activity. Involved in several processes, including chromatin looping; positive regulation of T-helper 17 cell lineage commitment; and protein localization to chromatin. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd2 |
| Official Name | bromodomain containing 2 [Source:MGI Symbol;Acc:MGI:99495] |
| Ensembl ID | ENSMUSG00000024335 |
| Bio databases IDs | |
| Aliases | bromodomain containing 2 |
| Synonyms | BRD2-IT1, bromodomain containing 2, D17H6S113E, D6S113E, Frg-1, FSH, FSHRG1, FSRG1, LOC100043003, LOC105375109, LOC108348112, mKIAA4005, NAT, O27.1.1, RING3, RNF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- histone binding
- degron
- protein binding activity, bridging
- chromatin binding
- protein binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Crohn disease
- lymphomagenesis
- acute tonsillitis
- inflammatory bowel disease
- ulcerative colitis
- tuberculosis
- pulmonary hypertensive arterial disease
- sarcoidosis
role in cell
- binding in
- expression in
- activation in
- production in
- transcription in
- growth
- assembly
- differentiation
- survival
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear speckles
- chromatin
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube closure
- protein localization to chromatin
- spermatogenesis
- positive regulation of T-helper 17 cell lineage commitment
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyl-lysine binding
- chromatin binding
- protein serine/threonine kinase activity