Brd2 Gene Summary [Mouse]
Enables lysine-acetylated histone binding activity. Involved in several processes, including chromatin looping; positive regulation of T-helper 17 cell lineage commitment; and protein localization to chromatin. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd2 |
| Official Name | bromodomain containing 2 [Source:MGI Symbol;Acc:MGI:99495] |
| Ensembl ID | ENSMUSG00000024335 |
| Bio databases IDs | |
| Aliases | bromodomain containing 2 |
| Synonyms | BRD2-IT1, bromodomain containing 2, D17H6S113E, D6S113E, Frg-1, FSH, FSHRG1, FSRG1, LOC100043003, LOC105375109, LOC108348112, mKIAA4005, NAT, O27.1.1, RING3, RNF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- histone binding
- degron
- protein binding activity, bridging
- chromatin binding
- protein binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Crohn disease
- lymphomagenesis
- acute tonsillitis
- inflammatory bowel disease
- ulcerative colitis
- tuberculosis
- pulmonary hypertensive arterial disease
- sarcoidosis
phenotypes
- abnormal auditory brainstem response
- abnormal vertebral arch morphology
- decreased CD8-positive alpha-beta T cell number
- decreased circulating calcium level
- decreased erythrocyte cell number
- increased CD4-positive alpha beta T cell number
- increased circulating HDL cholesterol level
- increased circulating amylase level
- increased circulating creatinine level
- increased mean corpuscular hemoglobin
- preweaning lethality complete penetrance
- abnormal Mullerian duct topology
- abnormal adenohypophysis morphology
- abnormal adipose tissue morphology
- abnormal aortic valve morphology
- abnormal blood homeostasis
- abnormal brain artery topology
- abnormal cell cycle
- abnormal cell death
- abnormal choroid plexus morphology
- abnormal circulating lipid level
- abnormal common carotid artery morphology
- abnormal craniofacial morphology
- abnormal ductus venosus morphology
- abnormal ductus venosus topology
- abnormal eating behavior
- abnormal embryo size
- abnormal embryonic neuroepithelial layer differentiation
- abnormal embryonic neuroepithelium morphology
- abnormal external carotid artery origin
- abnormal forebrain morphology
- abnormal gallbladder morphology
- abnormal hepatic portal vein connection
- abnormal hypoglossal nerve topology
- abnormal interatrial septum morphology
- abnormal lung position or orientation
- abnormal middle ear ossicle morphology
- abnormal nasal septum morphology
- abnormal neural tube closure
- abnormal neural tube morphology
- abnormal olfactory nerve morphology
- abnormal optic chiasm morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal pancreatic islet morphology
- abnormal pectinate muscle morphology
- abnormal physiological umbilical hernia morphology
- abnormal pineal gland morphology
- abnormal pulmonary valve morphology
- abnormal respiratory quotient
- abnormal semilunar valve morphology
- abnormal thymus topology
- abnormal umbilical vein topology
- abnormal vagus ganglion morphology
- abnormal vertebral artery topology
- abnormal vertebral body morphology
- absent connection between subcutaneous lymph vessels and lymph sac
- absent costovertebral joint
- absent eye muscles
- absent pectinate muscle
- absent superior cervical ganglion
- absent vagus nerve
- absent vertebral arch
- aorta coarctation
- aphakia
- artery stenosis
- atrioventricular septal defect
- basisphenoid bone foramen
- blood in lymph vessels
- common truncal valve
- decreased cell proliferation
- decreased circulating glucose level
- decreased embryo size
- decreased rib number
- double outlet right ventricle
- dual inferior vena cava
- duplication of ductus venosus
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- enlarged brain ventricles
- enlarged heart
- enlarged liver sinusoidal spaces
- exencephaly
- fetal growth retardation
- fusion of vertebral arches
- hemorrhage
- hepatic steatosis
- heterochrony
- improved glucose tolerance
- increased basal metabolism
- increased circulating adiponectin level
- increased circulating cholesterol level
- increased circulating glucagon level
- increased circulating insulin level
- increased circulating interleukin-1 beta level
- increased circulating leptin level
- increased circulating triglyceride level
- increased circulating tumor necrosis factor level
- increased embryonic neuroepithelium apoptosis
- increased embryonic neuroepithelium thickness
- increased embryonic tissue cell apoptosis
- increased epididymal fat pad weight
- increased fat cell size
- increased interscapular fat pad weight
- increased pancreatic beta cell number
- increased pancreatic islet number
- increased rib number
- increased total body fat amount
- interrupted aortic arch type b
- muscular ventricular septal defect
- myelocele
- obese
- pancreatic islet hyperplasia
- perimembraneous ventricular septal defect
- perinatal lethality incomplete penetrance
- persistent right dorsal aorta
- persistent trigeminal artery
- persistent truncus arteriosis
- postnatal lethality incomplete penetrance
- reduced sympathetic cervical ganglion size
- retroesophageal right subclavian artery
- retropleural edema
- rib bifurcation
- rib fusion
- scoliosis
- small kidney
- small thymus
- small thyroid gland
- subcutaneous edema
- thin myocardium compact layer
- thoracoschisis
- transposition of great arteries
role in cell
- binding in
- expression in
- activation in
- production in
- transcription in
- growth
- assembly
- differentiation
- survival
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear speckles
- chromatin
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube closure
- protein localization to chromatin
- spermatogenesis
- positive regulation of T-helper 17 cell lineage commitment
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyl-lysine binding
- chromatin binding
- protein serine/threonine kinase activity