Dusp6 Gene Summary [Mouse]
Enables phosphoprotein phosphatase activity. Acts upstream of or within negative regulation of protein phosphorylation; protein dephosphorylation; and regulation of heart growth. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp6 |
| Official Name | dual specificity phosphatase 6 [Source:MGI Symbol;Acc:MGI:1914853] |
| Ensembl ID | ENSMUSG00000019960 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 6 |
| Synonyms | 1300019I03Rik, DSP6, dual specificity phosphatase 6, HH19, MKP-3, PYST1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase interacting domain
- nuclear export signal
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- catalytic domain
- phosphoprotein phosphatase
- Rhodanese Homology Domain
- Rhodanese-like domain
- PTP_DSP_cys
- Cdc25 domain
- protein binding
- RHOD
- fxfp sequence
- PTPase domain
- Dual specificity phosphatase, catalytic domain
- CH2 domain (from immunoglobulin)
- MAP kinase phosphatase
- protein phosphatase
- phosphatase
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Dusp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- epileptic seizure
- heart failure
- encephalocele
- metabolic syndrome X
- susceptibility to Kallmann syndrome type 19
- insomnia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Kallmann syndrome type 19
role in cell
- apoptosis
- expression in
- proliferation
- production in
- cell death
- activation in
- phosphorylation in
- survival
- migration
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart growth
- response to growth factor stimulus
- negative regulation of MAPK cascade
- response to organic cyclic compound
- response to xenobiotic stimulus
- ERK1 and ERK2 cascade
- MAPK cascade
- negative regulation of protein phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- cell differentiation
- response to nitrosative stress
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- MAP kinase tyrosine phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity